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Viagra experienced no impact on saquinavir pharmacokinetics. A more powerful CYP3A4 inhibitor such as ketoconazole or itraconazole might be anticipated to acquire better impact than that found with saquinavir. Populace pharmacokinetic information from clients in scientific trials also indicated a discount in sildenafil clearance when it absolutely was co-administered with CYP3A4 inhibitors (which include ketoconazole, erythromycin, or cimetidine) [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS].
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